COVID-19 Drugs

Internal standards for therapeutic drug monitoring of potential COVID-19 drugs

Many laboratories and hospitals around the world are carrying out studies to find a solution against the spread of COVID-19 virus. Several drugs are on the test bench such as Hydroxychloroquine, Favipiravir or Remdesivir. Used alone or in combination with other drugs, these molecules demonstrate promising results. In order to develop and set up dosage methods, e.g. to determine the optimal doses, clinical studies based on therapeutic drug monitoring by LC-MS will be needed.

An Europe-wide clinical trial, called "Discovery", was launched to test four experimental treatments for COVID-19, including the following compounds: Remdesivir, Lopinavir and Ritonavir, Hydroxychloroquine. This trial will also complement the data that will be collected during another international clinical trial, called "Solidarity". Shimadzu and Alsachim are supporting these clinical trials by providing internal standards for therapeutic drug monitoring of these potential anti-COVID-19 drugs.

Related Drug Product Name Pack of 1mg
Favipiravir Favipiravir ALC-C8720-01
[13C,15N]-Favipiravir ALC-C8853-01
Lopinavir and Ritonavir
Lopinavir ALC-C2745-01
[2H8]-Lopinavir ALC-C4693-01
Ritonavir ALC-C2792-01
[13C,2H3]-Ritonavir ALC-C2963-01
Remdesivir and GS 441524
(Active Metabolites of Nucleoside
analog, Remdesivir)
Remdesivir ALC-C8799-01
[13C6]-Remdesivir (Mixture of Diastereoisomers) ALC-C8854-01
GS 441524 / CAS 1191237-69-0
[13C5]-GS 441524 ALC-C8855-01
Chloroquine and  Hydroxychloroquine
Chloroquine diphosphate
[2H5]-Chloroquine oxalate salt ALC-C5023-01
Hydroxychloroquine sulfate
[2H5]-Hydroxychloroquine dioxalate salt ALC-C6422-01
Desethylchloroquine diphosphate
[2H5]-Desethylchloroquine dioxalate salt ALC-C2453-01
Azithromycin dihydrate
[13C,2H3]-Azithromycin ALC-C1768-01
Nafamostat Mesylate Nafamostat Mesylate ALC-C8848-01
[13C6]-Nafamostat Mesylate ALC-C8849-01

All products are delivered with a detailed Certificate of Analysis

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