EBF

Poster

• Bioanalytical assay data comparison of bevacizumab quantitation in clinical plasma samples using LC-MS/MS, ELISA, and microfluidic immunoassay
  Takashi Shimada¹, Noriko Iwamoto¹, Jiichiro Sasaki², and Akinobu Hamada³  
  1 : Shimadzu Scientific Instruments, Bothell, WA
  2 : Kitasato University School of Medicine, Sagamihara, Japan
  3 : National Cancer Center Research Institute, Tokyo, Japan
   

• Multiplexed LC-MS/MS bioanalysis of therapeutic antibodies for inflammatory immune diseases using Fab-selective proteolysis nSMOL
  Takashi Shimada¹, Noriko Iwamoto¹, Kotoko Yokoyama², Atsushi Yonezawa^3,4, Masaya Denda^3,4, Motomu Hashimoto⁵, Masao Tanaka⁵, Hiromu Ito⁶, Minoru Matsuura⁷, Shuji Yamamoto⁷, Yusuke Honzawa⁷, and Kazuo Matsubara³
  1 : Shimadzu Scientific Instruments, Bothell, WA
  2 : Shimadzu Corporation, Kyoto, Japan
  3 : Kyoto University Hospital, Kyoto, Japan
  4: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  5: Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  6: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  7: Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
   

Product Lineup

• LCMS-9030: “A Q-TOF of Shimadzu’s engineering DNA! ”
  Ultra-fast acquisition rates and core ion beam technologies
   
   
  • Ultra-fast (UF) acquisition rates and core ion beam technologies developed for the triple quadrupole platform has opened-up new possibilities in quantitative mass spectrometry.
  • The new LCMS-9030 Q-TOF builds on this proven platform by rethinking time-of-flight detection.
  • In the LCMS-9030, core ion beam technologies transition towards a unique approach in ion gating using UFaccumulation to create a precise pulse of ions into the flight tube.
     
• New Nexera UHPLC System
  Shimadzu’s Nexera series of UHPLC systems offers groundbreaking technology in terms of intelligence, efficiency and design. Advanced AI capabilities and lab management using the Internet of Things (IoT) have been integrated to monitor performance and resource allocation. They make the new Nexera systems a leading-edge and user-friendly solution for versatile industries, setting new benchmarks in UHPLC.  
   
• Nexera Mikros: "Combines highest sensitivities of microflow LC with robustness of HPLC"
  Nano flowrate-compatible LC systems, used in combination with MS detectors, for their benefit in term of sensitivity, are step by step abandoned due to the drawbacks associated to their use: low speed, long analysis, tendency for pipies to clog, difficulties to solve leakages, ... In comparison, the microLC appears to be the perfect match between the need of sensivity and the ease of use. The Nexera-Mikros, with a wide range of flowrates from 1mL/min to 500 mL/min, will cover sensitivity needs while ensuring both durability and operability.
   
• Micro-ESI 9030 Micro-flow Ionization Unit
  Shimadzu’s Nexera Mikros microflow system combines the sensitivity improvements you expect from a low-flow system with the ruggedness of HPLC. Designed for optimal sensitivity and ease of use, the Micro-ESI 9030 interface brings microflow analysis to the Q-TOF
   
• MSW² Microsampling tool to collect volumetric samples of plasma
  The MSW² (RUO) is a unique microsampling tool to collect volumetric samples of plasma from reduced whole blood volume (23µl) on small animals.
   
• nSMOL nano-surface and molecular orientation limited proteolysis  
  An unparalleled convenient and rapid workflow provided by the nSMOL Antibody BA Kit to dramatically improve the productivity and robustness of LCMS mAb bioanalysis.